<p>The LisH motif is found in a large number of eukaryotic proteins, from metazoa, fungi and plants that have a wide range of functions. The recently solved structure of the LisH domain in the N-terminal region of LIS1 depicted it as a novel dimerization motif, and that other structural elements are likely to play an important role in dimerisation [<cite idref="PUB00031906"/>, <cite idref="PUB00035648"/>, <cite idref="PUB00035649"/>]. </p><p>The LisH (lis homology) domain mediates protein dimerisation and tetramerisation. The LisH domain is found in Sif2, a component of the Set3 complex which is responsible for repressing meiotic genes. It has been shown that the LisH domain helps mediate interaction with components of the Set3 complex [<cite idref="PUB00020892"/>]. </p> LisH dimerisation motif, subgroup